ONOMY Science

ONOMY Science  American journal of Cardiology and Cardiovascular diseases (AJCCVD),  Open Access ISSN 2641-2438 Using Artificial Intelligence to Catch Irregular Heartbeats           Thanks to advances in wearable health technologies, it’s now possible for people to monitor their heart rhythms at home for days, weeks, or even months via wireless electrocardiogram (EKG) patches. In fact, my Apple Watch makes it possible to record a real-time EKG whenever I want. (I’m glad to say I am in normal sinus rhythm.) For true medical benefit, however, the challenge lies in analyzing the vast amounts of data—often hundreds of hours worth per person—to distinguish reliably between harmless rhythm irregularities and potentially life-threatening problems. Now, NIH-funded researchers have found that artificial intelligence (AI) can help. A powerful computer “studied” more than 90,000 EKG recordings, from which it “learned” to recognize patterns, form rules, and apply them accurately

ONOMY Science American journal of Neurology & Neurophysiology (AJNN), OpenAccess ISSN 2642-3081  Spinal Cord Injury Heal with 3DPrinting           For people whose spinal cords are injured in traffic accidents, sports mishaps, or other traumatic events, cell-based treatments have emerged as a potential avenue for  encouraging healing . Now, taking advantage of advances in 3D printing technology, researchers have created customized implants that may boost the power of cell-based therapies for repairing injured spinal cords. Made of soft hydrogels that mimic spinal cord tissue, the implant pictured here measures just 2 millimeters across and is about as thick as a penny. It was specially designed to encourage healing in rats with spinal cord injuries. The tiny, open channels that surround the solid “H”-shaped core are designed to guide the growth of new neural extensions, keeping them aligned properly with the spinal cord. When left on their own, neural cells have

American journal of Nephrology & Therapeutics (AJNT): ISSN 2643-7007 Kidney Transplant Rejection          A kidney transplant can greatly improve the quality of life for people with kidney failure. But about 20% of donated kidneys are attacked and destroyed by the recipient’s immune system. Transplant rejection can happen despite daily treatments that suppress the immune system.          To help prevent rejection, doctors try to ensure that the recipient and donor are a good genetic match. This includes measuring a group of proteins found on the body’s cells called human leukocyte antigens (HLAs). HLAs help the immune system tell which cells belong to the body and which might belong to foreign invaders, such as bacteria. The more HLAs that match between a kidney donor and recipient, the more likely a transplant is to be successful. But even a kidney perfectly matched by HLAs can be rejected. This has led scientists to look for other proteins that might drive rej

Hepatitis C Care Cascade In IV Drug Users ONOMY Science  Scientific Journal of Gastroenterology and Hepatology   (SJGH) - ISSN:   2641-5585           Many people who are infected with the hepatitis C virus (HCV) remain undiagnosed and untreated. Although those born between 1946 and 1964 represent most of the population with  chronic  HCV infection,  persons who inject drugs (PWID) now make up the largest population of new cases of the disease. Up to 90% of all new HCV infections worldwide and at least 75% of those in the United States are attributed to the use of injected drugs.           An estimated 10 million PWID are infected with HCV worldwide, creating a significant infectious reservoir for the continued spread of this virus. Control of HCV infection among PWID will require targeted strategies to address the “HCV cascade of care”—enhancing diagnosis, linking individuals to HCV care, increasing treatment uptake, and enhancing viral cure. New Drug Users at R

Phospho Sensitivity from a Small Population of Cells          Phosphorylation is a key process in the regulation of protein activity and has long been appreciated as an essential mechanism for the control of cellular function - tells a protein where to go, what to bind to and even when to die.  However, the challenge of studying phosphorylation and other post-translational modifications with traditional proteomic methods arise from small spectrometric signals that are hard to detect with conventional tandem mass spectrometry (MS/MS), and even more difficult when there is little material to analyze.  MS/MS signals from small peptides by adding a boosting sample.  This TMT labeled boosting sample combined with the study sample increases the total signal above the MS/MS detection threshold, prompting the ionization of the entire sample, and subsequently allowing data analysis.  This method termed the ‘Boosting to Amplify Signal with Isobaric Labeling’ (BASIL) strategy, tricks

Immunotherapy Drug for Patients with HPV-Related Cancers        Immunotherapy drugs shrank the tumors of some patients with advanced  human papillomavirus  (HPV)-related cancers. The drug, bintrafusp alfa (also called M7824), was designed to  simultaneously bind to two target proteins —PD-L1 and TGF-beta—that help prevent the immune system from effectively attacking tumor cells.               Human  Papillomavirus  slow-growing cancer can be found early with regular Pap smear, also called a Pap test, a procedure in which cells are scraped from the cervix and looked at under a microscope. Mortality rates have been decreasing in the United States, thanks largely to the widespread use of the Pap smear as a screening tool. In addition to the Pap smear, DNA tests can also detect HPV strains that pose a cervical cancer risk. Cervical cancer incidence and mortality, however, remain significantly higher in low-income countries.        Symptoms of this disease often go undetected unti